Biochem/physiol Actions

The gene MAP1LC3A (microtubule associated protein 1 light chain 3 α) or LC3 or autophagy-related protein 8A (APG8A) encodes a protein that serves as a marker of autophagosomes. It is found to be expressed on surviving oligodendrocytes in Nasu-Hakola disease brains and may be involved in the induction of oligodendrogliopathy.

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General description

The gene autophagy-related protein 8A (APG8A), also referred to as MAP1LC3A (microtubule associated protein 1 light chain 3 α), is a homologue of Apg8p necessary for autophagy in yeast. The cytosolic form of the protein, upon processing, gets localized to the autophagosome membranes. The LC3 gene is mapped to human chromosome 20q11.22.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide